JWH-018, or Naphthalen-1-yl-(1-pentylindol-3-yl)methanone, is a synthetic cannabinoid containing a substituted indole structure.
JWH-018 is a potent cannabinoid receptor agonist with mild selectivity for CB2 (Ki values are 2.94 and 9.0 nM for CB2 and CB1 receptors respectively).
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It produces effects in animals similar to those of tetrahydrocannabinol (THC), a cannabinoid naturally present in cannabis, leading to its use in synthetic cannabis products that in some countries are sold legally as “incense blends”. Order JWH-018 online from Euro Mega Lab
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Metabolism of JWH-018 was assessed using Wistar rats which had been administered an ethanolic extract containing JWH-018. Urine was collected for 24 hours, followed by extraction of JWH-018 metabolites using both liquid-liquid extraction and solid-phase extraction. GC-MS was utilized to separate and identify the extracted compounds.
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JWH-018 and its N-dealkylated metabolite were only detected in small amounts, with hydroxylated N-dealkylated metabolites comprising the primary signal. The observed mass shift indicates that it is likely that hydroxylation occurs in both the naphthalene and indole portions of the molecule. Human metabolites were similar although most metabolism took place on the indole ring and pentyl side chain, and the hydroxylated metabolites were extensively conjugated with glucuronide.