N-Methyl-Cyclazodone

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Description

N-Methyl-Cyclazodone is an approximately 2x – 4x more potent derivative of the nootropic and psychostimulant compound Pemoline.

Chemical Name 2-(Cyclopropyl(methyl)amino)-5-phenyl-1,3-oxazol-4-one
CAS Number 14461-92-8
Purity ≥98%
Form White or off-white powder
Molecular Weight 230.26 g/mol
Melting Point 94-95°C
Molecular Formula C13H14N2O2
Synonyms   N-Cyclopropyl-N-Methylpemoline, 2-(Cyclopropyl(methyl)amino)-5-phenyl-2-oxazolin-4-one, 2-(Cyclopropyl(methyl)amino)-5-phenyloxazol-4(5H)-one, LD 4202

 

N-Methyl-Cyclazodone provided particularly strong central stimulant and motor excitant properties, such that a dose of 1 mg/kg in the mouse proved the compound to be equal in potency to d-amphetamine, but longer lasting in effect. The anorexigenic effect of the compound was also similar to that of d-amphetamine; however, unlike d-amphetamine, the compound was not a convulsant, had substantially lower toxicity, and had only a very slight cardiovascular effect in doses up to 5 mg/kg parenterally in the cat or dog.

N-Methyl-Cyclazodone is an N,N-disubstituted pemoline derivative. As an N,N-disubstituted compound, the literature indicates that Thozalinone shows milder and less potent, but potentially more sustained stimulant and antidepressant effects than N-monoalkyl pemoline derivatives. By analogy, this could suggest the possibility that the pharmacological effects of N-Methyl-Cyclazodone could be slightly milder and less potent, but longer lasting than those of Cyclazodone. Also likely as a result of N,N-disubstitution, the patents disclosed that N-Methyl-Cyclazodone (in comparison to Cyclazodone) had a comparatively lower melting point of 94-95°C.